{"manuscript_title":"<b>Mechanistic Insights into Non-coding RNAs in Sporadic Vestibular Schwannoma: A Comprehensive Review</b>","abstract":"Sporadic vestibular schwannoma (SVS) is a benign tumor arising from Schwann cells of the vestibular nerve. Because of its confined anatomical location, SVS often compresses adjacent cranial nerves and the brainstem, leading to hearing impairment and balance dysfunction. Recent evidence has revealed that non‑coding RNAs (ncRNAs), notably microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play pivotal roles in SVS tumorigenesis and progression by modulating cell proliferation, apoptosis, metabolism, and key signaling cascades. This review summarizes current knowledge of aberrant ncRNA expression in SVS, emphasizing miRNA associations with tumor volume, growth rate, and hearing loss, alongside emerging insights into lncRNA, and circRNA mediated regulation of proliferation and apoptosis. Mechanistically, ncRNAs influence pathways such as Hippo, PI3K/AKT, HIF-1, and MAPK, and several ncRNAs have demonstrated potential as therapeutic targets. Although most studies to date employ in vitro models, ncRNAs offer promising biomarker and treatment avenues for early diagnosis and precision therapy in SVS. Future research must focus on clinical specimen validation and detailed mechanistic exploration to facilitate the translation of ncRNA‑targeted approaches into practice.","keywords":["Sporadic vestibular schwannoma","miRNA","lncRNA","circRNA","signal pathway","biomarker"]}