{"manuscript_title":"<b>Effect of vitamin D combined with probiotic-assisted insulin pump on glucose-lipid metabolism, intestinal flora and pregnancy outcome in gestational diabetes mellitus</b>","abstract":"<b>Objective:</b> This study aimed to observe the effect of vitamin D combined with probiotic-assisted insulin pump on glucose-lipid metabolism, intestinal flora and pregnancy outcome in gestational diabetes mellitus (GDM).<b>Methods:</b> The study group and the control group were established (75 cases each). Both groups were treated until the delivery of the baby. The glycemic metabolic indices, lipid metabolic indices, improvement of gut microbiota indicators, blood glucose compliance rate, delivery method, and adverse pregnancy outcomes were compared in both groups.<b>Results:</b> After treatment, HDL-C, Bifidobacterium and Lactobacillus were increased in both groups (<i>P</i> < 0.05), and FINS, FPG, 2hPG, HbA1c, LDL-C, TC, TG, Coccidioides, Enterobacteriaceae, and Saccharomycetes were all reduced (<i>P</i> < 0.05); and all of them were improved in the study group versus the control group (<i>P</i> < 0.05). The study group exhibited higher blood glucose compliance rate, lower cesarean section rate, and lower overall incidence of adverse pregnancy outcomes versus the control group.<b>Conclusion:</b> Vitamin D combined with probiotics assisted insulin pump therapy for GDM can significantly improve the patient’s glucose and lipid metabolism levels, maintain intestinal microbiota balance, and reduce adverse pregnancy outcomes.","keywords":["Gestational diabetes mellitus","Vitamin D","Probiotics","Insulin pump","Glycolipid metabolism","Intestinal microbiota","Pregnancy outcome"]}